Quarterbacks are the leaders of the offensive team, responsible for calling the play in the huddle. They initiate almost all plays by receiving the ball from the center, although occasionally teams will use a "direct snap" to another offensive player. Once the quarterback receives the snap, he can run with the ball, hand the ball to another player or attempt a forward pass.

At most levels, but especially at the college and professional level, the quarterback role is one of the most visible and important roles on the team. The quarterback touches the ball on nearly every offensive play and has a great deal of responsibility both in calling plays and making decisions during the play. While there is liberal substitution at most positions in football based on the play call and to minimize player fatigue, most quarterbacks are on the field for every offensive play leaving only for injury or when the game's outcome is no longer in doubt.